It can be easily be indicated that Shupavu and Ushari have known each other for a long amount of time. The first time we see them interact is in The Rise of Scar, where Ushari, fed up with being trampled on by the residents of the Pridelands (Including The Lion Guard), hatches a plan to get revenge by summoning Scar. For his plan to work, he asks Shupavu for a favor. She asks if there's something in it for her. He then tells her that if everything goes as planned, the fate of the Pridelands could be tipped in their favor, gaining her interest.
Fans of this pair even create ships, according to which the two are a couple.
Aside from Ushari, Scar is the only evil creature Shupavu takes orders from. Because of her never failing to bring him the good news that he can use for his plans, the evil Lion always praises the sneaky lizard for her work. She has only failed him on two occasions.
Shupavu is an ally of Kiburi. She and Njano introduced a gecko named Hodari to him as it was the gecko's dream to join a crocodile float as Njano believed that he could use him to murder the leader of the Pride Lander crocodiles, Makuu. They also worked with the rest of Scar's Army to trap the Lion Guard and Makini as an attempt to stop them from saving Simba.
Upon detecting that Kinyonga is spying on Scar, Shupavu sees her as an enemy and tries to eliminate her with the help from her fellow skinks. Shupavu does not believe that Kinyonga will be a problem for her and her skinks, but the sneaky chameleon manages to evade capture until the Lion Guard arrive.
In Swept Away, Beshte found an ally in Shupavu and her skinks, as they offered to lead him to Rocky Plateau. Beshte even called them friends. However, this was a mere ruse as they attempted to lead Beshte into a trap which involved Janja, Cheezi, and Chungu trying to crush him with rocks. When spotting Janja and his hyenas, Beshte called for the skinks to run, not knowing they were on the hyena's side, not his. In The Scorpion's Sting, when Shupavu and her skulk reveal themselves with Ushari, Beshte appears to be shocked to see the lizards on the bad guys' side and hates them since.
The same as the rest of the Guard, Shupavu may hate them, but is too scared to fight them without the whole Army. When the Lion guard appeared to stop her and her Skulk from harming Kinyonga, Bunga, along with Kion, were the only members to order them away.
Hodari was cautious of Shupavu after hearing her voice. After she reveals herself and offers Hodari the opportunity to be part of a crocodile float, Hodari is overjoyed and trustingly follows her into the Outlands to meet Kiburi.
Since he never found out that Shupavu was working alongside Kiburi, it is presumed that Hodari remains unaware of her true intentions.
Shupavu hates Makini. When Simba got stung by a scorpion, Rafiki sends Makini and the Lion Guard to get the cure - volcanic ash. Shupavu also attacked Makini and the Guard when Scar called out his whole army.
Shupavu doesn't like Jasiri. After hearing that Jasiri has been working with the Lion Guard she goes to tell Scar what's been going on. She explains how Jasiri's Clan has set up a Hyena Resistance which is the reason why Scar's plans have been getting ruined.
Shupavu hates Kion since he is the leader of the Lion Guard. In The Scorpion's Sting, she works with the rest of the army to try and get rid of the Lion Guard and kill Kion's father Simba. In Undercover Kinyonga she tries to go after Kinyonga when she found out that Kinyonga was spying on Scar. However, Kion's Lion Guard comes to stop the skinks.
Shupavu knows that Kiara is Kion's sister and the future queen of the Pridelands. All through the two have never met Shupavu told Scar that she and her friends are at the mud pods and he plans to set the place on fire.
Shuapvu doesn't really like Rafiki. In The Rise of ScarShupavu helps Ushari and Janja's clan figure out how they can bring back Scar. She orders Nyeusi to go spy on Rafiki and Makini to see where they go.
Shupavu doesn't really like Makuu. In The Little Guy after finding out that Hodari wants to become a crocodile Makuu doesn't allow him in his float. However, Shupavu tells him that Kiburi has a float too. Hodari goes with Kiburi but Kiburi just uses him to attack Makuu. In Pride Landers Unite! the skinks find out that Kion asked Makuu if he could teach fellow Pride Landers his moves. Scar orders his army to take over, Makuu's Watering Hole.
To say that the two merely dislike each other would be untrue. Because she's mostly on Scar's good side, Shupavu sees herself above the male hyena and can be easily irritated by him at times, as seen in Undercover Kinyonga.