She knew Simba as a cub and the two were friends when they were kids. When they reunited several years later she fell in love and fought with Simba against Scar. Nala loves her mate very dearly and has a great deal of faith in him both as a mate, king, and father. When Simba is feeling doubtful over anything, Nala is always there to give him her support. She is also the one who is able to convince Simba into doing things, such as the Christmas performance for Timon and Pumbaa.
Nala fears for her mate whenever he is in severe danger, such as the time when he fell into a sinkhole in Bunga and the King, and when he becomes ill in The Scorpion's Sting, as she stays by his side until he is healed, showing her love and loyalty to her mate.
Nala appears to have a close mother-son relationship with her son Kion. Unlike Simba, she accepted that it was time for Kion to lead the Lion Guard, and showed immense pride in him when he defeated Janja and his clan and rescued Kiara. Kion cares about her deeply and becomes concerned about her whenever she's in danger, as seen in Never Roar Again. When Kion is blemished with the Mark of Evil, Nala is deeply concerned for her only son, and is utterly horrified when Rafiki reveals that there is no cure for him in the Pride Lands. After Kion departs for the Tree of Life, Nala continues to miss him months later and is overjoyed when she not only sees him return, but when he becomes King of the Tree of Life.
Nala and her daughter Kiara are shown to have a loving mother-daughter relationship, and Kiara enjoys learning about the importance of hunting and tracking from her. Nala always worries for her daughter whenever she's in danger and has faith in her knowing she can and will be a good future queen.
Nala has a good relationship with Simba's parents. Mufasa saved her from the hyenas when she was a cub. Sarabi helped her and Simba fight in the battle against Scar after finding out that it was he that killed Mufasa.
Zazu works for the queen as her Royal Advisor, who reports everything to her and Simba. He and Nala both helped encourage Simba to give his speech at Aminifu's funeral, showing how well the two work together.
When Nala first hears Kion's roar, she tells a doubting Simba to listen to Rafiki, knowing it is time for her son to fulfill his destiny.
Rafiki is a close friend of the royal family who always helps them out if they are sick or hurt. From what we have seen so far, the two seem to be good friends, with Nala having much trust in Rafiki as their Royal Mjuzi.
Not only are the birds of the Pride Lands fans of Hadithi, but the queen of the Pride Lands is also a fan of Hadithi too as she believed him to be a hero when they first met and has, in fact, praised him twice in the episode, Ono's Idol. She later watches the eagle praise Ono for his true bravery in the Royal Mud Print Ceremony.
When Kion introduced his parents to Ajabu, he explained that Ajabu had come to the Pride Lands as a visitor, but wished to stay with their blessing. Simba and Nala warmly agree, and Nala states their gladness to have him there.
Before his reformation, Makuu showed no loyalty towards the queen.
In Never Roar Again, after he and his float took over the Flood Plains, Nala informed Makuu that he was not entitled to owning them. Makuu refused and had two of his crocodiles pull the lioness into the water, using her as leverage against Kion. Regardless, Kion used the roar in a new unique way, blowing away the whole float, and then Makuu, thus saving Nala.
They both love being around Kiara's mom Nala. They always want to be with her no matter what she's doing. She also wants to impress the queen. However, she can be annoyed with them at times seen in The Underground Adventure, where they called the Lion Guard for a minor emergency.
Nala, Timon, and Pumbaa are good friends. After finding out that Bunga wants to put on a Christmas show to make Dandy Claws come. Just like her daughter Kiara; Nala wanted to be in the performance. She made Simba do it too since Timon and Pumbaa did so much for him.
When she confronts Janja and his clan in the Pride Lands, Nala orders them to go back into the Outlands, but instead, they attempt to attack her and have her surrounded until Kion roars at the hyenas out of anger until they are back where they belong. In The Rise of Scar, Janja threatens to kill her again as part of his plan to revive the spirit of Scar. He is also shown to have no respect for the queen at all. As seen in Never Roar Again, he believes that she is weak and powerless. However, it seems Nala has forgiven Janja for his actions as he can be seen cheering with the Pride Landers and the Royal Family when Simba announces that peace will return to the Pride Lands.
Nala sees Chungu, Cheezi, Nne, and Tano as enemies since they tried to attack her in Never Roar Again. However, it seems Nala has forgiven them for their actions as they can be seen cheering with the Pride Landers and the Royal Family when Simba announces that peace will return to the Pride Lands.
Nala hates Scar just as much as Simba. After Simba fled the Pride Lands following his father's death, she believed that Simba died alongside his father in the wildebeest stampede. However, Nala discovered that Simba survived when they were older and urged him to return to the Pride Lands and claim his rightful place as king. She stood by Simba's side when he fought Scar and after finding out that Scar was behind the murder of Mufasa.
Nala hated Zira since she was only loyal to Scar. Zira believed that Simba shouldn’t be king because Scar chose her son Kovu to be king and as Nala was Simba’s mate, Zira hated Nala in return. As Nuka never reformed, Nala’s opinions on him and vice versa likely never changed with the two sharing a mutual hatred.