Payton was born in Augusta, Georgia on May 16th, 1972. He got interested in acting in high school and as a teenager did stand up. After Payton graduated Southern Methodist University, he acted in some stage shows in Dallas, Texas.
Khary Payton's most notable role is the voice of the DC Comics character Cyborg. Some of his other roles include Josh in Emily's Reasons Why Not, Beasly in Generator Rex, and Hex in Ben 10.